BACKGROUND Previous research documents an association between adverse childhood experiences (ACEs) and immune system inflammation. High chronic inflammation is believed to be one biological pathway through which childhood adversity may affect health into adulthood. The Blackfeet tribal community has high rates of childhood trauma and community members are disproportionately affected by inflammatory diseases. PURPOSE To investigate whether belonging to the tribal community may moderate the relationship between childhood trauma and immune system inflammation in the Blackfeet tribal community. METHODS In a sample of 90 adults residing on the Blackfeet reservation, we measured ACEs belonging to the tribal community and two markers of immune system inflammation, interleukin-6 (IL-6) and C-reactive protein (CRP). RESULTS We found that independent of age, gender, annual income, body mass index, and depressive symptoms, belonging to the tribal community and ACEs interacted to predict levels of both IL-6 and CRP (B= -.37, t[81] = -3.82, p < .001, R2 change = .07 and B = -.29, t[81] = -2.75, p = .01, R2 change = .08, respectively). The association between ACEs and markers of immune system inflammation was statistically significant for community members who reported low levels of belonging to the community. CONCLUSIONS The findings of this study have important implications for intervention research seeking to reduce risk for inflammatory diseases for at-risk populations. Fostering stronger connections to the larger tribal community may positively affect risk for inflammatory diseases. Future work should examine the behavioral and psychosocial pathways through which stronger connections to community may confer health benefits.

中文翻译：

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居住在Blackfeet保留区的成年人的不良童年经历和免疫系统炎症：归属感的调节作用。

背景技术先前的研究记录了不良儿童时期经历（ACE）与免疫系统炎症之间的关联。高度慢性​​炎症被认为是儿童逆境可能影响成年后健康的一种生物途径。Blackfeet部落社区儿童时期遭受的伤害很高，社区成员受到炎性疾病的影响尤其严重。目的调查Blackfeet部落社区中是否属于部落社区可以缓解儿童创伤与免疫系统炎症之间的关系。方法在居住在Blackfeet保留区的90位成年人的样本中，我们测量了属于部落社区的ACEs和免疫系统炎症的两个标志物，即白细胞介素6（IL-6）和C反应蛋白（CRP）。结果我们发现，不分年龄，性别，年收入，体重指数和抑郁症状的情况，部落社区和ACE相互影响以预测IL-6和CRP的水平（B = -.37，t [81] = -3.82，p <.001，R2变化= .07，B = -.29，t [81] = -2.75，p = .01，R2变化= .08）。ACE与免疫系统炎症标记物之间的关联对于报告社区归属水平较低的社区成员具有统计学意义。结论这项研究的结果对旨在降低高危人群炎性疾病风险的干预研究具有重要意义。与更大的部落社区建立更牢固的联系可能会积极影响发炎性疾病的风险。