The skin epidermis is a constantly renewing stratified epithelium that provides essential protective barrier functions throughout life. Epidermal stratification is governed by a step-wise differentiation program that requires precise spatiotemporal control of gene expression. How epidermal self-renewal and differentiation are regulated remains a fundamental open question. Cell-intrinsic and cell-extrinsic mechanisms that modify chromatin structure and interactions have been identified as key regulators of epidermal differentiation and stratification. Here, we will review the recent advances in our understanding of how chromatin modifiers, tissue-specific transcription factors, and force-induced nuclear remodeling processes function to shape chromatin and to control epidermal tissue development and homeostasis.

中文翻译：

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表皮发育和稳态中的表观遗传基因调控、染色质结构和力诱导的染色质重塑。

皮肤表皮是不断更新的分层上皮，在整个生命过程中提供基本的保护屏障功能。表皮分层由逐步分化程序控制，该程序需要对基因表达进行精确的时空控制。如何调节表皮自我更新和分化仍然是一个基本的悬而未决的问题。改变染色质结构和相互作用的细胞内在和细胞外在机制已被确定为表皮分化和分层的关键调节剂。在这里，我们将回顾我们对染色质修饰剂、组织特异性转录因子和力诱导的核重塑过程如何影响染色质和控制表皮组织发育和体内平衡的理解方面的最新进展。