Endometrial cancer is one of the most common gynecologic malignancies worldwide. Only 2 agents have been approved by Food and Drug Administration for endometrial cancer since 1971. There is a need to identify molecular targets to treat advanced endometrial cancer. The receptor for hyaluronic acid–mediated motility (RHAMM) is upregulated in various types of cancer. Here, we aimed to determine the clinical significance of RHAMM expression in endometrial cancer. Two hundred twenty-five cases of endometrial cancer, including serous and endometrioid types, and 8 cases of normal endometrium were used for studying RHAMM protein levels. The Cancer Genome Atlas database was also queried for RHAMM mRNA expression in endometrial cancer. Increased expression of RHAMM protein was seen in endometrial cancer compared with no or weak expression in normal endometrium. RHAMM expression positively correlated with tumor grade. RHAMM expression was significantly increased in endometrial serous carcinomas, which are high-grade, aggressive types of endometrial cancer, compared with the relatively less aggressive endometrioid carcinomas. RHAMM expression also correlated with the presence of lymphovascular invasion. RHAMM mRNA expression correlated with decreased survival in The Cancer Genome Atlas cohort. Therefore, increased RHAMM expression in endometrial cancer is associated with high-grade tumors and is indicative of more aggressive behavior. These findings suggest RHAMM as a prognostic factor in endometrial cancer and as a potential therapeutic target in advanced endometrial cancer for future studies.

中文翻译：

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透明质酸介导的运动 (RHAMM) 受体在子宫内膜癌中的表达与不良组织学参数和肿瘤进展有关

子宫内膜癌是全球最常见的妇科恶性肿瘤之一。自 1971 年以来，只有 2 种药物被食品和药物管理局批准用于治疗子宫内膜癌。需要确定治疗晚期子宫内膜癌的分子靶点。透明质酸介导的运动受体 (RHAMM) 在各种癌症中上调。在这里，我们旨在确定 RHAMM 表达在子宫内膜癌中的临床意义。225 例子宫内膜癌（包括浆液性和子宫内膜样型）和 8 例正常子宫内膜用于研究 RHAMM 蛋白水平。还查询了癌症基因组图谱数据库中 RHAMM mRNA 在子宫内膜癌中的表达。与正常子宫内膜中无表达或弱表达相比，在子宫内膜癌中观察到 RHAMM 蛋白表达增加。RHAMM 表达与肿瘤分级呈正相关。与侵袭性相对较低的子宫内膜样癌相比，RHAMM 表达在子宫内膜浆液性癌中显着增加，这是一种高级、侵袭性的子宫内膜癌。RHAMM 表达也与淋巴血管侵犯的存在相关。RHAMM mRNA 表达与癌症基因组图谱队列中的存活率降低相关。因此，子宫内膜癌中 RHAMM 表达增加与高级别肿瘤相关，并表明更具攻击性。