The Drosophila fat body is the primary organ of energy storage as well as being responsible for the humoral response to infection. Its physiological function is of critical importance to the survival of the organism; however, many molecular regulators of its function remain ill-defined. Here, we show that the Drosophila melanogaster bromodomain-containing protein FS(1)H is required in the fat body for normal lifespan as well as metabolic and immune homeostasis. Flies lacking fat body fs(1)h exhibit short lifespan, increased expression of immune target genes, an inability to metabolize triglyceride, and low basal AKT activity, mostly resulting from systemic defects in insulin signalling. Removal of a single copy of the AKT-responsive transcription factor foxo normalises lifespan, metabolic function, uninduced immune gene expression and AKT activity. We suggest that the promotion of systemic insulin signalling activity is a key in vivo function of fat body fs(1)h This article has an associated First Person interview with the first author of the paper.

中文翻译：

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fs(1)h 通过 AKT 和 FOXO 在果蝇中控制代谢和免疫功能并提高存活率。

果蝇的脂肪体是能量储存的主要器官，同时负责对感染的体液反应。它的生理功能对有机体的生存至关重要；然而，其功能的许多分子调节剂仍然不明确。在这里，我们展示了黑腹果蝇含溴结构域蛋白 FS(1)H 是正常寿命以及代谢和免疫稳态的脂肪体所必需的。缺乏脂肪体fs(1)h的果蝇寿命短，免疫靶基因表达增加，无法代谢甘油三酯，基础 AKT 活性低，主要是由于胰岛素信号传导的系统性缺陷。去除 AKT 反应性转录因子的单拷贝foxo 使寿命、代谢功能、未诱导的免疫基因表达和 AKT 活性正常化。我们认为促进全身胰岛素信号活性是脂肪体fs(1)h的关键体内功能本文有与该论文第一作者相关的第一人称采访。