Antigen presentation is the key first step in the establishment of an antigen-specific T cell response. Among professional antigen presenting cells (APCs), dendritic cells (DCs) are the major population responsible for the priming of both CD4+ and CD8+ naïve T cells. This priming requires physical interaction between the DC and the T cell; during which signals are exchanged that determine both the magnitude and the quality of the ensuing response. The nature of these signals varies widely depending on the nature of the antigen, the anatomical site in which they take place, and the phenotype of the antigen-presenting DC, making the study of the dynamics, microanatomical distribution and phenotypic variation of DCs a key part of our understanding of adaptive immunity. Here, we provide a brief survey of how our view of T cell activation by DCs has evolved over recent years as intravital multiphoton microscopy and other emerging technologies have expanded our ability to study these events in vivo.

中文翻译：

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研究体内树突状细胞和 T 细胞之间的相互作用。


抗原呈递是建立抗原特异性 T 细胞反应的关键第一步。在专职抗原呈递细胞 (APC) 中，树突状细胞 (DC) 是负责启动 CD4+ 和 CD8+ 初始 T 细胞的主要细胞群。这种启动需要 DC 和 T 细胞之间的物理相互作用；在此期间交换信号，决定随后响应的幅度和质量。这些信号的性质根据抗原的性质、它们发生的解剖部位以及抗原呈递 DC 的表型而有很大差异，这使得 DC 的动力学、显微解剖分布和表型变异的研究成为关键我们对适应性免疫的理解的一部分。在这里，我们简要概述了近年来随着活体多光子显微镜和其他新兴技术扩展了我们在体内研究这些事件的能力，我们对 DC 激活 T 细胞的看法是如何演变的。