IL-13 receptor alpha 1 (IL-13Rα1) associates with IL-4Rα to form a functional IL-4Rα/IL-13Rα1 heteroreceptor (HR) through which both IL-4 and IL-13 signal. Recently, HR expression was associated with the development of M2 type macrophages which function as antigen presenting cells (APCs). Herein, we show that a subset of thymic resident dendritic cells (DCs) expressing high CD11b (CD11bhi) and intermediate CD11c (CD11cint) arise in HR-sufficient but not HR-deficient mice. These DCs, which originate from the bone marrow are able to take up Ag from the peritoneum, traffic through the spleen and the lymph nodes and carry it to the thymus. In addition, since the DCs are able to present Ag to T cells, express high levels of the costimulatory molecule CD24, and comprise a CD8α+ subset, it is likely that the cells contribute to T cell development and perhaps negative selection of self-reactive lymphocytes.

中文翻译：

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IL-13Rα1 充足但 IL-13Rα1 缺陷的小鼠胸腺中出现独特的树突状细胞群。


IL-13 受体 α 1 (IL-13Rα1) 与 IL-4Rα 结合形成功能性 IL-4Rα/IL-13Rα1 异质受体 (HR)，IL-4 和 IL-13 均通过该受体发出信号。最近，HR 表达与 M2 型巨噬细胞的发育相关，M2 型巨噬细胞充当抗原呈递细胞 (APC)。在此，我们发现在 HR 充足但 HR 缺乏的小鼠中，存在表达高 CD11b (CD11bhi) 和中 CD11c (CD11cint) 的胸腺驻留树突状细胞 (DC) 子集。这些源自骨髓的 DC 能够从腹膜吸收 Ag，穿过脾脏和淋巴结并将其携带至胸腺。此外，由于 DC 能够向 T 细胞呈递 Ag，表达高水平的共刺激分子 CD24，并包含 CD8α+ 子集，因此这些细胞可能有助于 T 细胞发育，并可能促进自身反应的阴性选择。淋巴细胞。