The goal of alternatives assessment (AA) is to facilitate a comparison of alternatives to a chemical of concern, resulting in the identification of safer alternatives. A two stage methodology for comparing chemical alternatives was developed. In the first stage, alternatives are compared using a variety of human health effects, ecotoxicity, and physicochemical properties. Hazard profiles are completed using a variety of online sources and quantitative structure activity relationship models. In the second stage, alternatives are evaluated utilizing an exposure/risk assessment over the entire life cycle. Exposure values are calculated using screening-level near-field and far-field exposure models. The second stage allows one to more accurately compare potential exposure to each alternative and consider additional factors that may not be obvious from separate binned persistence, bioaccumulation, and toxicity scores. The methodology was utilized to compare phosphate-based alternatives for decabromodiphenyl ether (decaBDE) in electronics applications.

中文翻译：

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用于评估电子应用阻燃剂化学替代品的替代品评估仪表板框架。


替代品评估 (AA) 的目标是促进对受关注化学品的替代品进行比较，从而确定更安全的替代品。开发了比较化学替代品的两阶段方法。在第一阶段，使用各种人类健康影响、生态毒性和理化特性来比较替代品。危害概况是使用各种在线资源和定量结构活动关系模型完成的。在第二阶段，利用整个生命周期的暴露/风险评估来评估替代方案。曝光值是使用筛选级近场和远场曝光模型计算的。第二阶段允许人们更准确地比较每种替代品的潜在暴露，并考虑从单独的持久性、生物蓄积性和毒性评分中可能不明显的其他因素。该方法用于比较电子应用中十溴二苯醚 (decaBDE) 的磷酸盐替代品。