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Dietary Glycation Products Regulate Immune Homeostasis: Early Glycation Products Promote Prostate Cancer Cell Proliferation through Modulating Macrophages.
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2017-12-29 , DOI: 10.1002/mnfr.201700641
Yingjia Chen 1 , Nikolay M Filipov 2 , Tai L Guo 1
Affiliation  

Well‐controlled glycation (generally limited to the early stages) has been proposed as a strategy to improve the physiochemical properties of dietary proteins, but the functional studies of glycation products are mostly on advanced glycation end‐products (AGEs) rather than early glycation products (EGPs). Since cytokines are important modulators of various biological processes, this study aims to determine whether EGPs and AGEs affected immune homeostasis differentially and do so through modulating macrophage‐derived factors.

中文翻译:

膳食糖化产物调节免疫稳态:早期糖化产物通过调节巨噬细胞促进前列腺癌细胞的增殖。

有人提出将糖基化控制良好(通常仅限于早期阶段)作为改善膳食蛋白理化特性的策略,但是糖基化产物的功能研究主要针对晚期糖基化终产物(AGEs),而非早期糖基化产物(EGP)。由于细胞因子是各种生物过程的重要调节剂,因此本研究旨在确定EGP和AGEs是否以差异方式影响免疫稳态,并通过调节巨噬细胞衍生因子来实现。
更新日期:2017-12-29
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