ABSTRACT We aimed to measure concentrations of the commonly used artificial sweetener sucralose, following ingestion of doses reflecting a range of consumption and to compare concentrations in children and adults. Eleven adults consumed 355 mL water containing 0 mg (control), 68, 170, or 250 mg sucralose (equivalent to 1–4 diet sodas). A second group of adults (n = 11) consumed 355 mL Diet Rite Cola™ (68 mg sucralose and 41 mg acesulfame-potassium (ace-K)) or 68 mg sucralose and 41 mg ace-K in seltzer. Beverages were provided at separate visits in randomized order, prior to an oral glucose tolerance test. Eleven children consumed 0 or 68 mg sucralose in 240 mL water, in an identical study design. Blood was collected before beverage ingestion and serially for 120 min. Sucralose doses (corrected for weight) resulted in similar plasma concentrations in children and adults. Concentrations were comparable whether sucralose was administered in water, combined with ace-K, or in diet soda. Due to their lower body weight and blood volume, children have markedly higher plasma sucralose concentrations after the consumption of a typical diet soda, emphasizing the need to determine the clinical implications of sucralose use in children.

中文翻译：

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儿童和成人三氯蔗糖的血浆浓度

摘要 我们的目的是在摄入反映一系列消费的剂量后测量常用人造甜味剂三氯蔗糖的浓度，并比较儿童和成人的浓度。11 名成人饮用 355 毫升水，其中含有 0 毫克（对照）、68、170 或 250 毫克三氯蔗糖（相当于 1-4 杯无糖汽水）。第二组成人（n = 11）饮用了 355 毫升 Diet Rite Cola™（68 毫克三氯蔗糖和 41 毫克乙酰磺胺酸钾（ace-K））或 68 毫克三氯蔗糖和 41 毫克 ace-K 苏打水。在口服葡萄糖耐量试验之前，以随机顺序在单独的访问中提供饮料。在相同的研究设计中，11 名儿童在 240 毫升水中摄入了 0 或 68 毫克三氯蔗糖。在摄入饮料之前和连续 120 分钟收集血液。三氯蔗糖剂量（根据体重校正）导致儿童和成人的血浆浓度相似。无论三氯蔗糖是在水中给药、与 ace-K 组合还是在无糖苏打水中给药，其浓度都是可比的。由于体重和血容量较低，儿童在饮用典型的无糖汽水后血浆三氯蔗糖浓度显着升高，这强调了确定儿童使用三氯蔗糖的临床意义的必要性。