The henipaviruses Nipah virus and Hendra virus are highly pathogenic zoonotic paramyxoviruses which have caused fatal outbreaks of encephalitis and respiratory disease in humans. Despite the availability of a licensed equine Hendra virus vaccine and a neutralizing monoclonal antibody shown to be efficacious against henipavirus infections in non-human primates, there remains no approved therapeutics or vaccines for human use. To explore the possibility of developing small-molecule nucleoside inhibitors against henipaviruses, we evaluated the antiviral activity of 4'-azidocytidine (R1479), a drug previously identified to inhibit flaviviruses, against henipaviruses along with other representative members of the family Paramyxoviridae. We observed similar levels of R1479 antiviral activity across the family, regardless of virus genus. Our brief study expands the documented range of viruses susceptible to R1479, and provides the basis for future investigation and development of 4'-modified nucleoside analogs as potential broad-spectrum antiviral therapeutics across both positive and negative-sense RNA virus families.

中文翻译：

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4'-Azidocytidine（R1479）有效抑制肝炎病毒和其他副粘病毒。

肝炎病毒尼帕病毒和亨德拉病毒是高致病性人畜共患副粘病毒，已引起人类脑炎和呼吸系统疾病的致命暴发。尽管获得了许可的马类亨德拉病毒疫苗和中和性单克隆抗体，已证明对非人类灵长类动物的肝炎病毒感染有效，但仍没有批准的人类使用疗法或疫苗。为了探索开发针对小肠病毒的小分子核苷抑制剂的可能性，我们评估了以前鉴定为抑制黄病毒的药物4'-叠氮基胞苷（R1479）与副粘病毒科其他代表成员的抗小肠病毒的抗病毒活性。我们观察到整个家族中R1479抗病毒活性的水平相似，而与病毒属无关。