Dengue (DENV), West Nile (WNV) and Zika (ZIKV) viruses are mosquito-transmitted flaviviruses that cause thousands of human deaths and millions of illnesses each year. In the last decades, epidemic outbreaks of all three flaviviruses emerged and caused a major health and economical problem in many parts of the world. The increasing and expanding burden of flaviviruses has highlighted the need for effective human vaccines against all three viruses. This review provides an overview of the recent progress in DENV, WNV and ZIKV vaccines development with specific focus on candidates in human clinical development.

中文翻译：

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人黄病毒疫苗的最新进展。

登革热 (DENV)、西尼罗河 (WNV) 和寨卡 (ZIKV) 病毒是蚊子传播的黄病毒，每年会导致数千人死亡和数百万人患病。在过去的几十年里，所有三种黄病毒的流行病都出现了，并在世界许多地方造成了重大的健康和经济问题。黄病毒负担的增加和扩大突出了对针对所有三种病毒的有效人类疫苗的需求。本综述概述了 DENV、WNV 和 ZIKV 疫苗开发的最新进展，特别关注人类临床开发中的候选疫苗。