Many natural lectins have been reported to have antiviral activity. As some of these have been put forward as potential development candidates for preventing or treating viral infections, we have set out in this review to survey the literature on antiviral lectins. The review groups lectins by structural class and class of source organism we also detail their carbohydrate specificity and their reported antiviral activities. The review concludes with a brief discussion of several of the pertinent hurdles that heterologous proteins must clear to be useful clinical candidates and cites examples where such studies have been reported for antiviral lectins. Though the clearest path currently being followed is the use of antiviral lectins as anti-HIV microbicides via topical mucosal administration, some investigators have also found systemic efficacy against acute infections following subcutaneous administration.

中文翻译：

---

抗病毒凝集素：病毒进入的选择性抑制剂。


据报道，许多天然凝集素具有抗病毒活性。由于其中一些已被提出作为预防或治疗病毒感染的潜在开发候选药物，我们在这篇综述中着手调查有关抗病毒凝集素的文献。该综述按结构类别和来源生物类别对凝集素进行了分组，我们还详细介绍了它们的碳水化合物特异性和报告的抗病毒活性。该综述最后简要讨论了异源蛋白必须清除才能成为有用的临床候选物的几个相关障碍，并引用了抗病毒凝集素的此类研究报告的例子。尽管目前最明确的途径是通过局部粘膜给药使用抗病毒凝集素作为抗 HIV 杀菌剂，但一些研究人员还发现皮下给药后对急性感染具有全身功效。