Sonic hedgehog (Shh) is a secreted protein that controls the patterning of neural progenitor cells, and their neuronal and glial progeny, during development. Emerging findings suggest that Shh also has important roles in the formation and plasticity of neuronal circuits in the hippocampus, a brain region of fundamental importance in learning and memory. Shh mediates activity-dependent and injury-induced hippocampal neurogenesis. Activation of Shh receptors in the dendrites of hippocampal neurons engages a trans-neuronal signaling pathway that accelerates axon outgrowth and enhances glutamate release from presynaptic terminals. Impaired Shh signaling may contribute to the pathogenesis of several developmental and adult-onset neurological disorders that affect the hippocampus, suggesting a potential for therapeutic interventions that target Shh pathways.

中文翻译：

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Sonic Hedgehog 信号传导和海马神经可塑性


Sonic Hedgehog (Shh) 是一种分泌蛋白，在发育过程中控制神经祖细胞及其神经元和神经胶质后代的模式。新的研究结果表明，Shh 在海马体神经元回路的形成和可塑性中也发挥着重要作用，海马体是一个对学习和记忆至关重要的大脑区域。 Shh 介导活动依赖性和损伤诱导的海马神经发生。海马神经元树突中 Shh 受体的激活会参与跨神经元信号传导通路，加速轴突生长并增强突触前末梢的谷氨酸释放。 Shh 信号传导受损可能导致多种影响海马体的发育性和成人发病的神经系统疾病的发病机制，这表明针对 Shh 通路的治疗干预措施具有潜力。