RNA nanostructures can be programmed to exhibit defined sizes, shapes and stoichiometries from naturally occurring or de novo designed RNA motifs. These constructs can be used as scaffolds to attach functional moieties, such as ligand binding motifs or gene expression regulators, for nanobiology applications. This review is focused on four areas of importance to RNA nanotechnology: the types of RNAs of particular interest for nanobiology, the assembly of RNA nanoconstructs, the challenges of cellular delivery of RNAs in vivo, and the delivery carriers that aid in the matter. The available strategies for the design of nucleic acid nanostructures, as well as for formulation of their carriers, make RNA nanotechnology an important tool in both basic research and applied biomedical science.

中文翻译：

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RNA 纳米颗粒的细胞递送。

RNA 纳米结构可以被编程为表现出来自天然存在或从头设计的 RNA 基序的确定的尺寸、形状和化学计量。这些构建体可用作支架来连接功能部分，例如配体结合基序或基因表达调节剂，用于纳米生物学应用。本综述重点关注 RNA 纳米技术的四个重要领域：纳米生物学特别感兴趣的 RNA 类型、RNA 纳米结构的组装、体内 RNA 细胞递送的挑战以及有助于解决这一问题的递送载体。核酸纳米结构设计及其载体配制的可用策略使 RNA 纳米技术成为基础研究和应用生物医学的重要工具。