Cells migrate through 3D environments using a surprisingly wide variety of molecular mechanisms. These distinct modes of migration often rely on the same intracellular components, which are used in different ways to achieve cell motility. Recent work reveals that how a cell moves can be dictated by the relative amounts of cell-matrix adhesion and actomyosin contractility. A current concept is that the level of difficulty in squeezing the nucleus through a confining 3D environment determines the amounts of adhesion and contractility required for cell motility. Ultimately, determining how the nucleus controls the mode of cell migration will be essential for understanding both physiological and pathological processes dependent on cell migration in the body.

中文翻译：

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3D迁移的多种机制：可塑性的起源。

细胞使用令人惊讶的多种分子机制在3D环境中迁移。这些不同的迁移模式通常依赖于相同的细胞内成分，这些成分以不同的方式用于实现细胞运动。最近的研究表明，细胞移动的方式可以由细胞基质粘附和肌动球蛋白收缩性的相对量决定。当前的概念是通过有限的3D环境挤压细胞核的难易程度决定了细胞运动所需的粘附和收缩量。最终，确定细胞核如何控制细胞迁移的方式对于理解依赖于人体细胞迁移的生理和病理过程至关重要。