Chromosome replication, gene expression and chromatin assembly all occur on the same template, necessitating a tight spatial and temporal coordination to maintain genomic stability. The distribution of replication initiation events is responsive to local and global changes in chromatin structure and is affected by transcriptional activity. Concomitantly, replication origin sequences, which determine the locations of replication initiation events, can affect chromatin structure and modulate transcriptional efficiency. The flexibility observed in the replication initiation landscape might help achieve complete and accurate genome duplication while coordinating the DNA replication program with transcription and other nuclear processes in a cell-type specific manner. This review discusses the relationships among replication origin distribution, local and global chromatin structures and concomitant nuclear metabolic processes.

中文翻译：

---

复制起源：核组织的决定因素或后果？


染色体复制、基因表达和染色质组装都发生在同一模板上，需要紧密的空间和时间协调以维持基因组稳定性。复制起始事件的分布响应染色质结构的局部和整体变化，并受到转录活性的影响。与此同时，决定复制起始事件位置的复制起点序列可以影响染色质结构并调节转录效率。在复制起始环境中观察到的灵活性可能有助于实现完整和准确的基因组复制，同时以细胞类型特定的方式协调 DNA 复制程序与转录和其他核过程。这篇综述讨论了复制起点分布、局部和整体染色质结构以及伴随的核代谢过程之间的关系。