The dendritic cells (DCs) of the immune system function in innate and adaptive responses by directing activity of various effector cells rather than serving as effectors themselves. DCs and closely related myeloid lineages share expression of many surface receptors, presenting a challenge in distinguishing their unique in vivo functions. Recent work has taken advantage of unique transcriptional programs to identify and manipulate murine DCs in vivo. This work has assigned several nonredundant in vivo functions to distinct DC lineages, consisting of plasmacytoid DCs and several subsets of classical DCs that promote different immune effector modules in response to pathogens. In parallel, a correspondence between human and murine DC subsets has emerged, underlying structural similarities for the DC lineages between these species. Recent work has begun to unravel the transcriptional circuitry that controls the development and diversification of DCs from common progenitors in the bone marrow.

中文翻译：

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树突状细胞发育的转录控制。

免疫系统的树突状细胞 (DC) 通过指导各种效应细胞的活动而不是作为效应器本身在先天和适应性反应中发挥作用。DCs 和密切相关的骨髓谱系共享许多表面受体的表达，这对区分它们独特的体内功能提出了挑战。最近的工作利用独特的转录程序在体内识别和操纵鼠 DC。这项工作为不同的 DC 谱系分配了几个非冗余的体内功能，包括浆细胞样 DC 和几个经典 DC 子集，它们促进不同的免疫效应模块以响应病原体。与此同时，人类和鼠类 DC 亚群之间的对应关系已经出现，这表明这些物种之间的 DC 谱系具有潜在的结构相似性。