Although skeletal muscle is one of the most regenerative organs in our body, various genetic defects, alterations in extrinsic signaling, or substantial tissue damage can impair muscle function and the capacity for self-repair. The diversity and complexity of muscle disorders have attracted much interest from both cell biologists and, more recently, bioengineers, leading to concentrated efforts to better understand muscle pathology and develop more efficient therapies. This review describes the biological underpinnings of muscle development, repair, and disease, and discusses recent bioengineering efforts to design and control myomimetic environments, both to study muscle biology and function and to aid in the development of new drug, cell, and gene therapies for muscle disorders. The synergy between engineering-aided biological discovery and biology-inspired engineering solutions will be the path forward for translating laboratory results into clinical practice.

中文翻译：

---

协同工程和生物学来治疗和建模骨骼肌损伤和疾病。

尽管骨骼肌是我们体内最再生的器官之一，但各种遗传缺陷，外在信号传导的改变或实质性组织损伤都会损害肌肉功能和自我修复能力。肌肉疾病的多样性和复杂性吸引了细胞生物学家和最近的生物工程师的极大兴趣，导致人们集中精力更好地了解肌肉病理学并开发出更有效的疗法。这篇综述描述了肌肉发育，修复和疾病的生物学基础，并讨论了最近的生物工程学努力，以设计和控制模拟肌环境，以研究肌肉生物学和功能，并帮助开发新的药物，细胞和基因疗法。肌肉疾病。