As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.

中文翻译：

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为脑疾病的体外研究创建患者特异性神经细胞。

作为一个小组，我们开会讨论了当前在创建有意义的患者特异性体外模型来研究脑部疾病方面面临的挑战。尽管实验室和患者群体之间的研究结果的融合为我们提供了信心和乐观，即基于 hiPSC 的平台将为未来的药物发现工作提供信息，但仍然存在许多关键的技术挑战。这篇意见文章概述了我们对基于 hiPSC 的疾病建模当前状态的集体观点，并讨论了我们认为必须作为一个领域集体解决的关键目标。