The T2 ribonuclease omega-1 is a powerful Th2-inducing factor secreted by the eggs of the blood fluke Schistosoma mansoni. Omega-1 can modulate pattern recognition receptor-induced inflammatory signatures and alter antigen presentation by dendritic cells. Recent findings have suggested that component(s) contained in or secreted by S. mansoni eggs (soluble egg antigen) can also enhance IL-1β secretion by dendritic cells stimulated with pattern recognition receptor ligands. Here we show that omega-1 enhances IL-1β secretion in macrophages stimulated with Toll-like receptor 2 ligand, and propose omega-1 as the factor in soluble egg antigen capable of regulating inflammasome activity. This effect is dependent on the C-type lectin receptor Dectin-1, caspase-8 and the ASC inflammasome adaptor protein, highlighting the ability of omega-1 to regulate multiple pattern recognition receptor signalling pathways. These mechanistic insights into manipulation of host immunity by a parasite product have implications for the design of anti-inflammatory therapeutic drugs.

中文翻译：

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曼氏血吸虫 T2 核糖核酸酶 omega-1 调节巨噬细胞中炎症小体依赖性 IL-1β 的分泌。

T2 核糖核酸酶 omega-1 是一种强大的 Th2 诱导因子，由曼氏血吸虫的卵分泌。Omega-1 可以调节模式识别受体诱导的炎症特征并改变树突状细胞的抗原呈递。最近的研究结果表明，曼氏沙门氏菌卵中含有或分泌的成分（可溶性卵抗原）也可以增强用模式识别受体配体刺激的树突状细胞分泌 IL-1β。在这里，我们显示 omega-1 增强了用 Toll 样受体 2 配体刺激的巨噬细胞中 IL-1β 的分泌，并提出 omega-1 作为可溶性卵抗原中能够调节炎症小体活性的因子。这种作用依赖于 C 型凝集素受体 Dectin-1、caspase-8 和 ASC 炎症小体衔接蛋白，强调 omega-1 调节多种模式识别受体信号通路的能力。这些对寄生虫产物操纵宿主免疫的机制见解对抗炎治疗药物的设计具有重要意义。