Planar polarity is a well-studied phenomenon resulting in the directional coordination of cells in the plane of a tissue. In invertebrates and vertebrates, planar polarity is established and maintained by the largely independent core and Fat/Dachsous/Four-jointed (Ft-Ds-Fj) pathways. Loss of function of these pathways can result in a wide range of developmental or cellular defects, including failure of gastrulation and problems with placement and function of cilia. This review discusses the conservation of these pathways across the animal kingdom. The lack of vital core pathway components in basal metazoans suggests that the core planar polarity pathway evolved shortly after, but not necessarily alongside, the emergence of multicellularity.

中文翻译：

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整个动物界的平面极性通路功能的保护。

平面极性是一种经过充分研究的现象，可导致细胞在组织平面中定向定向。在无脊椎动物和脊椎动物中，平面极性是由很大程度上独立的核心和脂肪/ Dachsous /四联（Ft-Ds-Fj）途径建立和维持的。这些途径的功能丧失可导致广泛的发育或细胞缺陷，包括胃泌素衰竭以及纤毛的放置和功能问题。这篇评论讨论了动物界中这些途径的保护。基底后生动物中缺乏重要的核心通路成分表明，核心平面极性通路在多细胞性出现后不久（但不一定同时出现）进化。