The human leukocyte receptor complex (LRC) encompasses several sets of genes with a common evolutionary origin and which form a branch of the immunoglobulin superfamily (IgSF). Comparisons of LRC genes both within and between species calls for a high degree of plasticity. The drive for this unprecedented level of variation is not known, but it relates in part to interaction of several LRC products with polymorphic human leukocyte antigen (HLA) class I molecules. However, the range of other proposed ligands for LRC products indicates a dynamic set of receptors that have adapted to detect target molecules relating to numerous cellular pathways. Several receptors in the complex bind a molecular signature in collagenous ligands. Others detect a variety of motifs relating to pathogens in addition to cellular stress, attesting to the opportunistic versatility of LRC receptors.

中文翻译：

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LRC 中受体对细胞和组织扰动的监测。

人类白细胞受体复合体 (LRC) 包含几组具有共同进化起源的基因，它们形成了免疫球蛋白超家族 (IgSF) 的一个分支。LRC 基因在物种内部和物种之间的比较需要高度的可塑性。这种前所未有的变异水平的驱动力尚不清楚，但它部分与几种 LRC 产品与多态性人类白细胞抗原 (HLA) I 类分子的相互作用有关。然而，LRC 产品的其他建议配体的范围表明一组动态受体已适应检测与许多细胞途径相关的靶分子。复合物中的几个受体结合胶原配体中的分子特征。除细胞压力外，其他人还检测到与病原体相关的各种基序，