Inflammation is an unstable state. It either resolves or persists. Why inflammation persists and the factors that define tissue tropism remain obscure. Increasing evidence suggests that tissue-resident stromal cells not only provide positional memory but also actively regulate the differential accumulation of inflammatory cells within inflamed tissues. Furthermore, at many sites of chronic inflammation, structures that mimic secondary lymphoid tissues are observed, suggesting that chronic inflammation and lymphoid tissue formation share common activation programs. Similarly, blood and lymphatic endothelial cells contribute to tissue homeostasis and disease persistence in chronic inflammation. This review highlights our increasing understanding of the role of stromal cells in inflammation and summarizes the novel immunological role that stromal cells exert in the persistence of inflammatory diseases.

中文翻译：

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基质细胞在慢性炎症和第三淋巴器官形成中。

炎症是不稳定状态。它可以解决或持续存在。为什么炎症持续存在以及定义组织嗜性的因素仍然不清楚。越来越多的证据表明，组织驻留间质细胞不仅提供位置记忆，而且还主动调节发炎组织内炎性细胞的差异积累。此外，在慢性炎症的许多部位，观察到模仿次级淋巴组织的结构，这表明慢性炎症和淋巴组织的形成具有共同的激活程序。类似地，血液和淋巴管内皮细胞有助于组织稳态和慢性炎症中的疾病持久性。