Invariant natural killer T (iNKT) cells recognize endogenous and exogenous lipids in the context of CD1d molecules, and through the activation and maturation of dendritic cells and B cells, can significantly enhance priming of antigen-specific T and B cell responses. Recent findings have provided important insights into the recognition of several novel endogenous lipids by iNKT cells, and into the mechanisms controlling their generation and loading onto CD1d molecules. In this review we discuss these latest findings and describe the role of autophagy in iNKT cell development and activation.

中文翻译：

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CD1d 依赖性内源性和外源性脂质抗原呈递。


恒定自然杀伤 T (iNKT) 细胞在 CD1d 分子的背景下识别内源性和外源性脂质，并通过树突状细胞和 B 细胞的激活和成熟，可以显着增强抗原特异性 T 和 B 细胞反应的启动。最近的研究结果为 iNKT 细胞识别几种新型内源性脂质，以及控制它们的生成和加载到 CD1d 分子上的机制提供了重要的见解。在这篇综述中，我们讨论了这些最新发现，并描述了自噬在 iNKT 细胞发育和激活中的作用。