Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium.,Molecular Nutrition & Food Research

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Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium.
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2015-03-16 , DOI: 10.1002/mnfr.201400734
Caren E Smith ₁ , Jack L Follis ₂ , Jennifer A Nettleton ₃ , Millennia Foy ₄ , Jason H Y Wu ₅ , Yiyi Ma ₁ , Toshiko Tanaka ₆ , Ani W Manichakul _{7,

8} , Hongyu Wu ₉ , Audrey Y Chu ₁₀ , Lyn M Steffen ₁₁ , Myriam Fornage _{3,

4} , Dariush Mozaffarian _{12,

13,

14} , Edmond K Kabagambe ₁₅ , Luigi Ferruci ₆ , Yii-Der Ida Chen ₁₆ , Stephen S Rich ₈ , Luc Djoussé _{17,

18} , Paul M Ridker _{10,

19} , Weihong Tang ₁₁ , Barbara McKnight ₂₀ , Michael Y Tsai ₂₁ , Stefania Bandinelli ₂₂ , Jerome I Rotter ₁₆ , Frank B Hu _{9,

23,

24,

25} , Daniel I Chasman _{10,

19} , Bruce M Psaty _{26,

27,

28} , Donna K Arnett ₂₉ , Irena B King ₃₀ , Qi Sun _{9,

24,

25} , Lu Wang ₁₀ , Thomas Lumley ₃₁ , Stephanie E Chiuve ₉ , David S Siscovick _{26,

27} , José M Ordovás _{1,

32,

33} , Rozenn N Lemaitre ₂₆

Affiliation

Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA*
Department of Mathematics, Computer Science, and Cooperative Engineering, University of St. Thomas, Houston, TX, USA.
Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
The George Institute for Global Health, The University of Sydney, Sydney, NSW, Australia.
Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, VA, USA.
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Division of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA.
Department of Epidemiology, Harvard School of Public Health, Harvard Medical School, Boston, MA, USA.
Department of Nutrition, Harvard School of Public Health, Harvard Medical School, Boston, MA, USA.
Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.
Division of Epidemiology, Department of Medicine, Vanderbilt University, Nashville, TN, USA.
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor, UCLA Medical Center, Torrance, CA, USA.
Division of Aging, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Boston Veterans Affairs Healthcare System, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
Department of Biostatistics, University of Washington, Seattle, WA, USA.
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Florence, Italy.
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Harvard School of Public Health, Boston, MA, USA.
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Cardiovascular Health Research Unit, Department of Medicine, Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
Department of Epidemiology, Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
Department of Health Services, Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
Department of Epidemiology, Section on Statistical Genetics, and The Office of Energetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Department of Internal Medicine, Division of Endocrinology, University of New Mexico, Albuquerque, NM, USA.
Department of Statistics, University of Auckland, Auckland, New Zealand.
Department of Epidemiology and Population Genetics, Centro Nacional Investigación Cardiovasculares (CNIC), Madrid, Spain.
Instituto Madrilenõs de Estudios Avanzados Alimentación, Madrid, Spain.

Tissue concentrations of omega‐3 fatty acids may reduce cardiovascular disease risk, and genetic variants are associated with circulating fatty acids concentrations. Whether dietary fatty acids interact with genetic variants to modify circulating omega‐3 fatty acids is unclear. We evaluated interactions between genetic variants and fatty acid intakes for circulating alpha‐linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid.

中文翻译：

膳食脂肪酸调节遗传变异与血浆和红细胞膜中循环脂肪酸之间的关联：对 CHARGE 联盟九项研究的荟萃分析。

omega-3 脂肪酸的组织浓度可能会降低心血管疾病的风险，而遗传变异与循环脂肪酸浓度相关。膳食脂肪酸是否与遗传变异相互作用以改变循环中的 omega-3 脂肪酸尚不清楚。我们评估了循环α-亚油酸、二十碳五烯酸、二十二碳六烯酸和二十二碳五烯酸的遗传变异和脂肪酸摄入量之间的相互作用。

更新日期：2015-03-16

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