Regulated antigen presentation to immune cells determines the effectiveness of an immune response. IL-10 is an immunosuppressive cytokine that regulates immune responses by inhibiting the ability of APCs to present antigens to T cells in a variety of ways. The mechanisms of IL-10-mediated immunosuppression include interference in TLR-mediated or IFNγ-mediated dendritic cell (DC) and macrophage activation as well as direct induction of genes that suppress APC function. In this review we will discuss current studies exploring the molecular mechanisms by which IL-10 suppresses APC function.

中文翻译：

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IL-10抑制抗原呈递。

调节的抗原呈递给免疫细胞决定了免疫反应的有效性。IL-10是一种免疫抑制性细胞因子，可通过抑制APC以多种方式将抗原呈递给T细胞的能力来调节免疫反应。IL-10-介导的免疫抑制的机制包括干扰TLR介导的或IFNγ介导的树突状细胞（DC）和巨噬细胞激活以及直接诱导抑制APC功能的基因。在这篇综述中，我们将讨论有关IL-10抑制APC功能的分子机制的最新研究。