The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway employed by diverse cytokines, interferons, growth factors, and related molecules. This pathway provides an elegant and remarkably straightforward mechanism whereby extracellular factors control gene expression. It thus serves as a fundamental paradigm for how cells sense environmental cues and interpret these signals to regulate cell growth and differentiation. Genetic mutations and polymorphisms are functionally relevant to a variety of human diseases, especially cancer and immune-related conditions. The clinical relevance of the pathway has been confirmed by the emergence of a new class of therapeutics that targets JAKs.

中文翻译：

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JAK-STAT 通路：对人类疾病和治疗干预的影响。


Janus 激酶 (JAK) - 转录激活因子 (STAT) 信号转导通路现在被认为是多种细胞因子、干扰素、生长因子和相关分子所采用的进化上保守的信号通路。该途径提供了一种优雅且非常简单的机制，细胞外因子可以通过该机制控制基因表达。因此，它作为细胞如何感知环境线索并解释这些信号以调节细胞生长和分化的基本范例。基因突变和多态性与多种人类疾病，特别是癌症和免疫相关疾病在功能上相关。一类针对 JAK 的新型疗法的出现证实了该通路的临床相关性。