ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflammatory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds, termed 11a and 12b, mirrored the helminth product both in inhibiting mast cell degranulation and cytokine responses in vitro and in preventing ovalbumin-induced Th2-associated airway inflammation and eosinophil infiltration of the lungs in mice. Furthermore, the two SMAs inhibited neutrophil infiltration of the lungs when administered therapeutically. ES-62-SMAs 11a and 12b thus represent starting points for novel drug development for allergies such as asthma.

中文翻译：

---

免疫调节寄生虫产品 ES-62 的小分子类似物具有抗过敏特性。

ES-62 是一种由丝状线虫 Acanthocheilonema vitae 分泌的糖蛋白，通过共价连接的磷酸胆碱部分表现出抗炎特性。筛选基于 ES-62 磷酸胆碱的小分子类似物 (SMA) 库显示，两种化合物，称为 11a 和 12b，在体外抑制肥大细胞脱粒和细胞因子反应以及预防卵白蛋白诱导的 Th2-相关的气道炎症和小鼠肺部的嗜酸性粒细胞浸润。此外，两种 SMA 在治疗性给药时抑制了肺的中性粒细胞浸润。因此，ES-62-SMAs 11a 和 12b 代表了哮喘等过敏症新药开发的起点。