Increasing evidence supports a central role for ncRNA in numerous aspects of chromatin function. For instance, ncRNAs can act as a scaffold for the recruitment of certain chromatin modifying complexes to specific sites within the genome. It is easily imaginable how this can occur in cis, but examples also exist whereby targeting of complexes by ncRNA occurs in trans to the site of transcription. Moreover, association of an ncRNA with a particular locus can trigger localization of the gene to a subnuclear structure harboring a specialized transcriptional environment. In this review, we discuss new insights into the mechanisms by which ncRNAs function in trans with respect to Polycomb Group, chromatin insulator, and dosage compensation complexes in mammals and/or Drosophila.

中文翻译：

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通过反式非编码 RNA 调节染色质修饰复合物。

越来越多的证据支持 ncRNA 在染色质功能的许多方面发挥核心作用。例如，ncRNA 可以充当支架，将某些染色质修饰复合物募集到基因组内的特定位点。很容易想象这如何以顺式发生，但也存在这样的例子，即 ncRNA 靶向复合物发生在转录位点的反式。此外，ncRNA 与特定位点的关联可以触发基因定位到包含特殊转录环境的亚核结构。在这篇综述中，我们讨论了关于哺乳动物和/或果蝇中的多梳群、染色质绝缘体和剂量补偿复合物的 ncRNA 反式功能机制的新见解。