Pattern recognition receptors (PRRs) are essential sentinels for pathogens or tissue damage and integral components of the innate immune system. Recent structural studies have provided unprecedented insights into the molecular mechanisms of ligand recognition and signal transduction by several PRR families at distinct subcellular compartments. Here we highlight some of the recent discoveries and summarize the common themes that are emerging from these exciting studies. Better mechanistic understanding of the structure and function of the PRRs will improve future prospects of therapeutic targeting of these important innate immune receptors.

中文翻译：

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模式识别受体的结构揭示了自抑制、配体识别和寡聚化的分子机制。

模式识别受体 (PRR) 是病原体或组织损伤的重要哨兵，也是先天免疫系统的组成部分。最近的结构研究为几个 PRR 家族在不同亚细胞区室的配体识别和信号转导的分子机制提供了前所未有的见解。在这里，我们重点介绍了一些最近的发现，并总结了这些令人兴奋的研究中出现的共同主题。更好地理解 PRR 的结构和功能将改善这些重要的先天免疫受体的治疗靶向的未来前景。