RNase III is a global regulator of gene expression in Escherichia coli that is instrumental in the maturation of ribosomal and other structural RNAs. We examine here how RNase III itself is regulated in response to growth and other environmental changes encountered by the cell and how, by binding or processing double-stranded RNA (dsRNA) intermediates, RNase III controls the expression of genes. Recent insight into the mechanism of dsRNA binding and processing, gained from structural studies of RNase III, is reviewed. Structural studies also reveal new cleavage sites in the enzyme that can generate longer 3' overhangs.

中文翻译：

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RNase III：遗传学和功能；结构和机制。

RNase III 是大肠杆菌基因表达的全局调节剂，有助于核糖体和其他结构 RNA 的成熟。我们在这里研究了 RNase III 本身如何响应细胞遇到的生长和其他环境变化而受到调节，以及 RNase III 如何通过结合或处理双链 RNA (dsRNA) 中间体来控制基因的表达。回顾了从 RNase III 的结构研究中获得的对 dsRNA 结合和加工机制的最新见解。结构研究还揭示了酶中新的切割位点，可以产生更长的 3' 突出端。