Adaptive immunity is characterized by the ability to form long-lived immunological memory. Upon re-exposure to antigen, memory T cells respond more rapidly and robustly than naïve T cells, providing better clearance of pathogens. Recent reviews have reinforced the text-book view that memory T cells arise from effector cells. Although this notion is teleologically appealing, emerging data are more consistent with a model where naïve cells directly develop into memory cells without transitioning through an effector stage. A clear understanding of the lineage relationships between memory and effector cells has profound implications for the design of vaccines and for the development of effective T cell-based therapies.

中文翻译：

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效应T细胞和记忆T细胞的谱系关系。


适应性免疫的特点是能够形成长期的免疫记忆。重新暴露于抗原后，记忆 T 细胞比幼稚 T 细胞反应更快、更强烈，从而更好地清除病原体。最近的评论强化了教科书上的观点，即记忆 T 细胞起源于效应细胞。尽管这个概念在目的论上很有吸引力，但新出现的数据更符合这样的模型：幼稚细胞直接发育成记忆细胞，而无需经过效应器阶段。清楚地了解记忆细胞和效应细胞之间的谱系关系对于疫苗的设计和基于 T 细胞的有效疗法的开发具有深远的影响。