Pluripotency is a property that early embryonic cells possess over a considerable developmental time span. Accordingly, pluripotent cell lines can be established from the pre-implantation or post-implantation mouse embryo as embryonic stem (ES) or epiblast stem (EpiSC) cell lines, respectively. Maintenance of the pluripotent phenotype depends on the function of specific transcription factors (TFs) operating within a pluripotency gene regulatory network (PGRN). As cells move from an ES cell to an EpiSC state, the PGRN changes with expression of some TFs reduced (e.g. Nanog) or eliminated (e.g. Esrrb). Re-expressing such TFs can move cells back to an earlier developmental identity and is being applied to attempt establishment of human cell lines with the properties of mouse ES cells.

中文翻译：

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多能性基因调控网络组件在介导多能细胞状态之间的转换中的作用。

多能性是早期胚胎细胞在相当长的发育时间跨度内拥有的特性。因此，多能细胞系可以从植入前或植入后小鼠胚胎分别建立为胚胎干 (ES) 或外胚层干 (EpiSC) 细胞系。多能表型的维持取决于在多能基因调控网络 (PGRN) 内运行的特定转录因子 (TF) 的功能。当细胞从 ES 细胞移动到 EpiSC 状态时，PGRN 会随着一些 TF 的表达减少（例如 Nanog）或消除（例如 Esrrb）而发生变化。重新表达此类 TF 可以使细胞恢复到早期的发育身份，并被用于尝试建立具有小鼠 ES 细胞特性的人类细胞系。