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Molecular nexopathies: a new paradigm of neurodegenerative disease
Trends in Neurosciences ( IF 14.6 ) Pub Date : 2013-10-01 , DOI: 10.1016/j.tins.2013.06.007
Jason D Warren 1 , Jonathan D Rohrer , Jonathan M Schott , Nick C Fox , John Hardy , Martin N Rossor
Affiliation  

Highlights • How proteinopathies damage brain networks is a key issue in neurodegenerative disease.• Here, we outline a solution based on the concept of ‘molecular nexopathies’.• The concept is founded on specific interactions of network and protein properties.• This new paradigm has far-reaching biological and clinical implications.

中文翻译:

分子神经病:神经退行性疾病的新范式

亮点 • 蛋白质病如何损害大脑网络是神经退行性疾病的一个关键问题。• 在这里,我们概述了基于“分子神经病”概念的解决方案。• 该概念基于网络和蛋白质特性的特定相互作用。• 这种新范式具有深远的生物学和临床意义。
更新日期:2013-10-01
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