The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depends profoundly on the dimensionality of the extracellular matrix (ECM). Here we review a number of evolving concepts revealed when cell migration is examined in different dimensions.

中文翻译：

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细胞迁移的维度。

在过去的 50 年中，细胞迁移对正常生理功能和疾病过程的重要性一直很明显。尽管对常规组织培养中二维 (2D) 迁移的研究阐明了许多重要的分子机制，但最近的证据表明细胞迁移在很大程度上取决于细胞外基质 (ECM) 的维度。在这里，我们回顾了在不同维度检查细胞迁移时揭示的一些不断发展的概念。