Year in and year out, influenza viruses exact a deadly and expensive toll on humanity. Current vaccines simply do not keep pace with viral immune evasion, providing partial protection, at best, among various age groups. A quantum leap in understanding the basic principles of the adaptive and innate immune responses to influenza viruses offers the opportunity to develop vaccines that forestall, and potentially ultimately defeat, influenza virus antigenic variation.

中文翻译：

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实现不可能的梦想：普遍接种流感疫苗。

年复一年，流感病毒给人类造成了致命和昂贵的损失。目前的疫苗根本无法跟上病毒免疫逃逸的步伐，充其量只能在不同年龄段提供部分保护。对流感病毒的适应性和先天免疫反应基本原理的巨大飞跃为开发预防并可能最终击败流感病毒抗原变异的疫苗提供了机会。