The innate lymphoid cell (ILC) family has recently expanded with the discovery of type-2 innate lymphoid cells (ILC2). These cells arise from lymphoid progenitors in the bone marrow and, under the control of the transcriptional regulators RORα and Gata3, they mature to give rise to IL-5, IL-9 and IL-13 producing ILC2. These cells are critical components of the innate immune response to parasitic worm infections and have also been implicated in the pathogenesis of asthma and allergy. Recent advances in our understanding of the molecular regulation of ILC2 development and function now present the opportunity to develop new genetic models to assess ILC2 immune function and to investigate possible therapeutic interventions.

中文翻译：

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第2组先天淋巴细胞的发育和功能。

先天淋巴细胞 (ILC) 家族最近随着 2 型先天淋巴细胞 (ILC2) 的发现而扩大。这些细胞起源于骨髓中的淋巴祖细胞，在转录调节因子 RORα 和 Gata3 的控制下，它们成熟产生产生 IL-5、IL-9 和 IL-13 的 ILC2。这些细胞是对寄生虫感染的先天免疫反应的关键组成部分，也与哮喘和过敏的发病机制有关。我们对 ILC2 发育和功能的分子调控理解的最新进展现在为开发新的遗传模型以评估 ILC2 免疫功能和研究可能的治疗干预提供了机会。