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Hypothalamic tanycytes: potential roles in the control of feeding and energy balance
Trends in Neurosciences ( IF 14.6 ) Pub Date : 2013-02-01 , DOI: 10.1016/j.tins.2012.12.008
Matei Bolborea 1 , Nicholas Dale
Affiliation  

Tanycytes, glial-like cells that line the third ventricle, are emerging as components of the hypothalamic networks that control body weight and energy balance. They contact the cerebrospinal fluid (CSF) and send processes that come into close contact with neurons in the arcuate and ventromedial hypothalamic nuclei. Tanycytes are glucosensitive and are able to respond to transmitters associated with arousal and the drive to feed. At least some tanycytes are stem cells and, in the median eminence, may be stimulated by diet to generate new neurons. The quest is on to understand how tanycytes detect and respond to changes in energy balance and how they communicate with the rest of the nervous system to effect their functions.

中文翻译:

下丘脑长红细胞:在控制进食和能量平衡方面的潜在作用

Tanycytes,排列在第三脑室的神经胶质样细胞,正在成为控制体重和能量平衡的下丘脑网络的组成部分。它们接触脑脊液 (CSF) 并发送与弓状和腹内侧下丘脑核中的神经元密切接触的过程。Tanycytes 是葡萄糖敏感的,并且能够响应与唤醒和进食驱动相关的发射器。至少一些tanycytes是干细胞,并且在中间隆起时,可以通过饮食刺激产生新的神经元。探索是要了解 tanycytes 如何检测和响应能量平衡的变化,以及它们如何与神经系统的其他部分交流以影响它们的功能。
更新日期:2013-02-01
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