The National Institute of Environmental Health Sciences (NIEHS) has a rich history in evaluating the toxicity of mixtures. The types of mixtures assessed by the Division of the National Toxicology Program (DNTP) and the extramural community (through the Division of Extramural Research and Training, DERT) have included a broad range of chemicals and toxicants, with each study having a unique set of questions and design considerations. Some examples of the types of mixtures studied include: groundwater contaminants, pesticides/fertilizers, dioxin-like chemicals (assessing the toxic equivalency approach), drug combinations, air pollution, metals, polycyclic aromatic hydrocarbons, technical mixtures (e.g., pentachlorophenol, flame retardants), and mixed entities (e.g., herbals, asbestos). These endeavors have provided excellent data on the toxicity of specific mixtures and have been informative to the human health risk assessment process in general (e.g., providing data on low dose exposures to environmental chemicals). However, the mixtures research effort at NIEHS, to date, has been driven by test article nominations to the DNTP or by investigator-initiated research through DERT. Recently, the NIEHS has embarked upon an effort to coordinate mixtures research across both intramural and extramural divisions in order to maximize mixtures research results. A path forward for NIEHS mixtures research will be based on feedback from a Request for Information (RFI) designed to gather up-to-date views on the knowledge gaps and roadblocks to evaluating mixtures and performing cumulative risk assessment, and a workshop organized to bring together mixtures experts from risk assessment, exposure science, biology, epidemiology, and statistics. The future of mixtures research at NIEHS will include projects from nominations to DNTP, studies by extramural investigators, and collaborations across government agencies that address high-priority questions in the field of mixtures research.

中文翻译：

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NIEHS 的混合物研究：一个不断发展的项目。

美国国家环境健康科学研究所 (NIEHS) 在评估混合物的毒性方面拥有丰富的历史。国家毒理学计划司 (DNTP) 和校外社区（通过校外研究和培训司 DERT）评估的混合物类型包括广泛的化学品和毒物，每项研究都有一套独特的问题和设计考虑。研究混合物类型的一些例子包括：地下水污染物、杀虫剂/化肥、二恶英类化学品（评估毒性当量方法）、药物组合、空气污染、金属、多环芳烃、技术混合物（例如五氯苯酚、阻燃剂） ）和混合实体（例如草药、石棉）。这些努力提供了有关特定混合物毒性的优秀数据，并且为一般人类健康风险评估过程提供了信息（例如，提供了低剂量暴露于环境化学品的数据）。然而，迄今为止，NIEHS 的混合物研究工作一直是由 DNTP 的测试文章提名或研究者通过 DERT 发起的研究推动的。最近，NIEHS 开始努力协调校内和校外部门的混合物研究，以最大限度地提高混合物研究成果。NIEHS 混合物研究的前进道路将基于信息请求 (RFI) 的反馈，该信息请求旨在收集有关评估混合物和执行累积风险评估的知识差距和障碍的最新观点，并组织研讨会以来自风险评估、暴露科学、生物学、流行病学和统计学的专家汇集在一起​​。NIEHS 混合物研究的未来将包括从提名到 DNTP 的项目、校外研究人员的研究以及解决混合物研究领域高优先级问题的政府机构之间的合作。