当前位置: X-MOL 学术Schizophr. Bull. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Social disadvantage: cause or consequence of impending psychosis?
Schizophrenia Bulletin ( IF 5.3 ) Pub Date : 2012-10-24 , DOI: 10.1093/schbul/sbs112
Simona A Stilo 1 , Marta Di Forti , Valeria Mondelli , Aurora M Falcone , Manuela Russo , Jennifer O'Connor , Emma Palmer , Alessandra Paparelli , Anna Kolliakou , Miriam Sirianni , Heather Taylor , Rowena Handley , Paola Dazzan , Carmine Pariante , Tiago R Marques , Rocco Zoccali , Anthony David , Robin M Murray , Craig Morgan
Affiliation  

BACKGROUND An association between social disadvantage and established psychosis is well documented in the literature, but there remains a lack of data on the social circumstances of patients before they became ill. We investigated whether social disadvantage at, and prior to, first contact with psychiatric services, is associated with psychosis. METHOD We collected information on social disadvantage in childhood and adulthood from 278 cases presenting with their first episode of psychosis to the South London and Maudsley National Health Service Foundation Trust and from 226 controls recruited from the local population. Three markers of childhood social disadvantage and 3 markers of disadvantage in adulthood were analyzed. RESULTS Long term separation from, and death of, a parent before the age of 17 years were both strongly associated with a 2- to 3-fold-increased odds of psychosis. Cases were also significantly more likely to report 2 or more markers of adult social disadvantage than healthy controls (OR = 9.03) at the time of the first presentation with psychosis, independent of a number of confounders. When we repeated these analyses for long-standing adult social disadvantage, we found that the strength of the association decreased but still remained significant for 1 year (OR = 5.67) and 5 years (OR = 2.57) prior to the first contact. CONCLUSIONS Social disadvantage indexes exposure to factors operating prior to onset that increase the risk of psychosis, both during childhood and adulthood.

中文翻译:

社会劣势:即将发生的精神病的原因或后果?

背景 社会劣势与已确立的精神病之间的关联在文献中有充分的记录,但仍然缺乏关于患者患病前社会环境的数据。我们调查了第一次接触精神科服务时和之前的社会劣势是否与精神病有关。方法 我们收集了来自伦敦南部和莫兹利国家卫生服务基金会信托基金的 278 例首发精神病病例以及从当地招募的 226 名对照者的童年和成年期社会劣势的信息。分析了儿童社会劣势的三个标志和成年后的三个劣势标志。结果 长期分离和死亡,17 岁之前的父母都与 2 至 3 倍的精神病几率密切相关。与健康对照组相比,病例在首次出现精神病时更可能报告 2 个或更多成人社会劣势标记(OR = 9.03),与许多混杂因素无关。当我们对长期存在的成人社会劣势重复这些分析时,我们发现关联的强度有所下降,但在第一次接触之前的 1 年(OR = 5.67)和 5 年(OR = 2.57)仍然显着。结论 社会劣势指数暴露于发病前会增加精神病风险的因素,无论是在儿童期还是成年期。与健康对照组相比,病例在首次出现精神病时更可能报告 2 个或更多成人社会劣势标记(OR = 9.03),与许多混杂因素无关。当我们对长期存在的成人社会劣势重复这些分析时,我们发现关联的强度有所下降,但在第一次接触之前的 1 年(OR = 5.67)和 5 年(OR = 2.57)仍然显着。结论 社会劣势指数暴露于发病前会增加精神病风险的因素,无论是在儿童期还是成年期。与健康对照组相比,病例在首次出现精神病时更可能报告 2 个或更多成人社会劣势标记(OR = 9.03),与许多混杂因素无关。当我们对长期存在的成人社会劣势重复这些分析时,我们发现关联的强度有所下降,但在第一次接触之前的 1 年(OR = 5.67)和 5 年(OR = 2.57)仍然显着。结论 社会劣势指数暴露于发病前会增加精神病风险的因素,无论是在儿童期还是成年期。我们发现,在第一次接触前 1 年(OR = 5.67)和 5 年(OR = 2.57),关联强度有所下降,但仍显着。结论 社会劣势指数暴露于发病前会增加精神病风险的因素,无论是在儿童期还是成年期。我们发现,在第一次接触前 1 年(OR = 5.67)和 5 年(OR = 2.57),关联强度有所下降,但仍显着。结论 社会劣势指数暴露于发病前会增加精神病风险的因素,无论是在儿童期还是成年期。
更新日期:2012-10-22
down
wechat
bug