Many regeneration contexts require the presence of regenerating nerves as a transient component of the progenitor cell niche. Here we review nerve involvement in regeneration of various structures in vertebrates and invertebrates. Nerves are also implicated as persistent determinants in the niche of certain stem cells in mammals, as well as in Drosophila. We consider our present understanding of the cellular and molecular mechanisms underlying nerve dependence, including evidence of critical interactions with glia and non-neural cell types. The example of the salamander aneurogenic limb illustrates that developmental interactions between the limb bud and its innervation can be determinative for adult regeneration. These phenomena provide a different perspective on nerve cells to that based on chemical and electrical excitability.

中文翻译：

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组织、器官和附肢再生中的神经依赖性

许多再生环境需要存在再生神经作为祖细胞生态位的短暂组成部分。在这里，我们回顾了脊椎动物和无脊椎动物各种结构再生中的神经参与。神经也被认为是哺乳动物和果蝇中某些干细胞生态位的持久决定因素。我们考虑了我们目前对神经依赖的细胞和分子机制的理解，包括与神经胶质细胞和非神经细胞类型的关键相互作用的证据。蝾螈神经源性肢体的例子表明，肢芽与其神经支配之间的发育相互作用可能是成人再生的决定性因素。这些现象为基于化学和电兴奋性的神经细胞提供了不同的视角。