In recent years, much progress has been made in understanding the process by which the brain is organised into specific regions. Much less is known about the way neuronal subtypes are defined inside these areas and how the temporal control of connectivity between neurons is achieved. Our thought processes and behaviours depend upon the development of neuronal circuits located in the most anterior brain area: the telencephalon (forming our cerebral cortex). The transcription factor Foxg1 is crucial to the development of specific neuronal fates inside this region and recent findings in zebrafish and mouse unveiled its impact as an integrator of telencephalic signalling centres. This essential regulatory activity may be key to understand Foxg1-dependent human disorders.

中文翻译：

---

一只狐狸阻止了 Wnt：对前脑发育和疾病的影响。

近年来，在理解大脑被组织成特定区域的过程方面取得了很大进展。关于在这些区域内定义神经元亚型的方式以及如何实现神经元之间连接的时间控制，我们知之甚少。我们的思维过程和行为取决于位于最前部大脑区域的神经元回路的发展：端脑（形成我们的大脑皮层）。转录因子 Foxg1 对该区域内特定神经元命运的发展至关重要，最近在斑马鱼和小鼠身上的发现揭示了它作为端脑信号中心整合者的影响。这种重要的调节活动可能是了解 Foxg1 依赖性人类疾病的关键。