The proper choice of the CD4-helper or CD8-cytotoxic lineages by developing T cells is crucial for the generation of an antigen-responsive and functionally fit T cell repertoire. Here we present a brief overview of the transcriptional control of this process, with emphasis on two issues. The study of Cd4 expression, that had previously generated important paradigms for transcriptional regulation in eukaryotic cells, now brings new twists to the concept of 'epigenetic memory'. And connections are emerging between transcriptional regulators critical for commitment to either lineage. The present review attempts to integrate these findings and discusses the still elusive mechanisms that match CD4-CD8 lineage differentiation to MHC specificity.

中文翻译：

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胸腺中的 CD4-CD8 分化：连接电路和建立记忆。

通过开发 T 细胞正确选择 CD4 辅助细胞或 CD8 细胞毒性谱系对于产生抗原反应性和功能适合的 T 细胞库至关重要。在这里，我们简要概述了该过程的转录控制，重点是两个问题。Cd4 表达的研究以前为真核细胞中的转录调控产生了重要的范例，现在为“表观遗传记忆”的概念带来了新的变化。转录调节因子之间的联系对任一谱系的承诺至关重要。本综述试图整合这些发现，并讨论将 CD4-CD8 谱系分化与 MHC 特异性相匹配的仍然难以捉摸的机制。