Suicide and related behaviors are complex phenomena associated with different risk factors. Although most individuals who display suicidal behavior do not have a history of early-life adversity, a significant minority does. Recent animal and human data have suggested that early-life adversity leads to epigenetic regulation of genes involved in stress-response systems. Here, we review this evidence and suggest that early-life adversity increases risk of suicide in susceptible individuals by influencing the development of stable emotional, behavioral and cognitive phenotypes that are likely to result from the epigenetic regulation of the hypothalamic-pituitary-adrenal axis and other systems involved in responses to stress.

中文翻译：

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自杀行为的神经发育起源

自杀和相关行为是与不同风险因素相关的复杂现象。尽管大多数表现出自杀行为的人没有早年经历过逆境，但也有少数人有。最近的动物和人类数据表明，早期生活中的逆境会导致参与压力反应系统的基因的表观遗传调控。在这里，我们回顾了这一证据并表明，早期生活逆境通过影响稳定的情绪、行为和认知表型的发展而增加易感个体的自杀风险，这些表型可能是由下丘脑 - 垂体 - 肾上腺轴的表观遗传调节和参与应对压力的其他系统。