OBJECTIVES Although luteinizing hormone to follicular stimulating hormone (LH/FSH) ratio is a controversial criterion for identifying a sub-group of infertile women with polycystic ovary syndrome (PCOS) and abnormalities at the level of the hypothalamic-pituitary-ovarian axis, an elevated LH/FSH ratio is frequently observed in PCOS cases. Obesity and insulin resistance are highly prevalent among PCOS women. To date, no studies have examined the associations of LH/FSH ratio with these co-morbid conditions outside the context of pre- and peri-menopausal PCOS women. The objective of this study is to evaluate whether the LH/FSH ratio is associated with obesity, insulin resistance, metabolic disturbances and chronic inflammation among post-menopausal U.S. women, 35-60 years of age. STUDY DESIGN Cross-sectional study of 693 women who participated in the 1999-2002 National Health and Nutrition Examination Survey. MAIN OUTCOME MEASURES Body mass index, waist circumference, triglycerides, high-density lipoprotein (HDL) cholesterol, systolic and diastolic blood pressures, fasting glucose, metabolic syndrome, Homeostasis Model Assessment for Insulin Resistance and C-reactive protein (CRP). RESULTS Age- and hysterectomy-adjusted regression models suggest that CRP level is positively associated with LH/FSH ratio and LH/FSH>1, high glucose level and LH/FSH>2 are inversely related and HDL<50mg/dL is positively associated with both LH/FSH>1 and LH/FSH>2. CONCLUSIONS In a nationally representative sample of post-menopausal women, markers of chronic inflammation and dyslipidemia which are characteristics of PCOS-associated morbidities were also significantly associated with LH/FSH ratio, meriting further investigation.

中文翻译：

---

美国绝经后女性肥胖相关紊乱与 LH/FSH 比值的关系


目的 虽然黄体生成素与卵泡刺激素 (LH/FSH) 的比率是一个有争议的标准，用于识别患有多囊卵巢综合征 (PCOS) 和下丘脑 - 垂体 - 卵巢轴水平异常的不孕妇女亚组，但LH/FSH 比率在 PCOS 病例中经常观察到。肥胖和胰岛素抵抗在多囊卵巢综合症女性中非常普遍。迄今为止，除了绝经前和围绝经期 PCOS 女性之外，还没有研究探讨 LH/FSH 比值与这些共病的关系。本研究的目的是评估 35-60 岁美国绝经后女性的 LH/FSH 比值是否与肥胖、胰岛素抵抗、代谢紊乱和慢性炎症相关。研究设计 对参加 1999-2002 年全国健康和营养检查调查的 693 名妇女进行横断面研究。主要指标体重指数、腰围、甘油三酯、高密度脂蛋白（HDL）胆固醇、收缩压和舒张压、空腹血糖、代谢综合征、胰岛素抵抗稳态模型评估和C反应蛋白（CRP）。结果年龄和子宫切除调整的回归模型表明，CRP 水平与 LH/FSH 比值和 LH/FSH>1 呈正相关，高血糖水平与 LH/FSH>2 呈负相关，HDL<50mg/dL 与 LH/FSH>1 呈正相关。 LH/FSH>1 和 LH/FSH>2。结论 在具有全国代表性的绝经后妇女样本中，作为 PCOS 相关发病特征的慢性炎症和血脂异常标志物也与 LH/FSH 比值显着相关，值得进一步研究。