The hippocampus integrates the encoding, storage and recall of memories, binding the spatio-temporal and sensory information that constitutes experience and keeping episodes in their correct context. The rapid and accurate processing of such daunting volumes of continuously changing data relies on dynamically assigning different aspects of mnemonic processing to specialized, interconnected networks corresponding to the anatomical subfields of dentate gyrus (DG), CA3 and CA1. However, differentially processed information ultimately has to be reintegrated into conjunctive representations, and this is unlikely to be achieved by unidirectional, sequential steps through a DG-CA3-CA1 loop. In this Review, we highlight recently discovered anatomical and physiological features that are likely to necessitate updates to the hippocampal circuit diagram, particularly by incorporating the oft-neglected CA2 region.

中文翻译：

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更新海马体表征：CA2 加入回路

海马体整合了记忆的编码、存储和回忆，结合了构成经验的时空和感官信息，并将情节保持在正确的上下文中。对如此大量不断变化的数据进行快速准确的处理依赖于将助记符处理的不同方面动态分配给与齿状回 (DG)、CA3 和 CA1 的解剖子域相对应的专用互连网络。然而，差异处理的信息最终必须重新整合到连接表示中，这不太可能通过 DG-CA3-CA1 循环的单向、顺序步骤来实现。在这篇评论中，我们重点介绍了最近发现的可能需要更新海马回路图的解剖学和生理学特征，