BACKGROUND Neuroimaging studies in humans have implicated both dysfunction of the medial temporal lobe (MTL) and the dopamine system in psychosis, but the relationship between them is unclear. We addressed this issue by measuring MTL activation and striatal dopaminergic function in individuals with an At Risk Mental State (ARMS) for psychosis, using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), respectively. METHODS Thirty-four subjects (20 ARMS and 14 Controls), matched for age, gender, digit span performance, and premorbid IQ, were scanned using fMRI, while performing a verbal encoding and recognition task, and using 18F-DOPA PET. All participants were naïve to antipsychotic medication. RESULTS ARMS subjects showed reduced MTL activation when encoding words and made more false alarm responses for Novel words than controls. The relationship between striatal dopamine function and MTL activation during both verbal encoding and verbal recognition was significantly different in ARMS subjects compared with controls. CONCLUSION An altered relationship between MTL function and dopamine storage/synthesis capacity exists in the ARMS and may be related to psychosis vulnerability.

中文翻译：

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精神病超高风险人群内侧颞叶与皮质下多巴胺功能之间的异常关系。


背景人类神经影像学研究表明内侧颞叶（MTL）和多巴胺系统的功能障碍与精神病有关，但它们之间的关系尚不清楚。我们通过分别使用功能磁共振成像 (fMRI) 和正电子发射断层扫描 (PET) 测量具有精神病风险精神状态 (ARMS) 的个体的 MTL 激活和纹状体多巴胺能功能来解决这个问题。方法 34 名受试者（20 名受试者和 14 名对照者），年龄、性别、数字跨度表现和病前智商相匹配，使用 fMRI 进行扫描，同时执行语言编码和识别任务，并使用 18F-DOPA PET。所有参与者均未接受过抗精神病药物治疗。结果 与对照组相比，ARMS 受试者在编码单词时表现出 MTL 激活减少，并且对新单词做出更多的误报反应。与对照组相比，ARMS 受试者在言语编码和言语识别过程中纹状体多巴胺功能与 MTL 激活之间的关系显着不同。结论 ARMS 中 MTL 功能与多巴胺储存/合成能力之间存在改变的关系，并且可能与精神病脆弱性有关。