Large portions of the genome undergo alternative pre-mRNA splicing in often intricate patterns. Alternative splicing regulation requires extensive control mechanisms since errors can have deleterious consequences and may lead to developmental defects and disease. Recent work has identified a complex network of regulatory RNA elements which guide splicing decisions. In addition, the discovery that transcription and splicing are intimately coupled has opened up new directions into alternative splicing regulation. Work at the interface of chromatin and RNA biology has revealed unexpected molecular links between histone modifications, the transcription machinery, and non-coding RNAs (ncRNAs) in the determination of alternative splicing patterns.

中文翻译：

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不仅仅是剪接代码：整合 RNA、染色质和非编码 RNA 在选择性剪接调控中的作用。

基因组的大部分以通常复杂的模式进行替代的前 mRNA 剪接。可变剪接调控需要广泛的控制机制，因为错误会产生有害的后果，并可能导致发育缺陷和疾病。最近的工作已经确定了一个复杂的调控 RNA 元件网络，它指导剪接决策。此外，转录和剪接密切耦合的发现为可变剪接调控开辟了新的方向。染色质和 RNA 生物学界面的工作揭示了组蛋白修饰、转录机制和非编码 RNA (ncRNA) 之间在确定可变剪接模式方面出人意料的分子联系。