Cohesin complexes hold sister chromatids together, which is essential for proper chromosome segregation during cell division and for post-replicative DNA repair. Recent studies suggest that, in addition to this global role in chromosome biology, cohesin is recruited to specific chromosomal locations by CTCF, and perhaps by other sequence-specific DNA binding factors. Once in position, cohesin controls chromosome conformation at the local level. Could this be key to understanding cohesin's role in gene expression?

中文翻译：

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Cohesin：染色体生物学领域的全球参与者，与基因调控有局部联系。


粘连蛋白复合物将姐妹染色单体结合在一起，这对于细胞分裂过程中正确的染色体分离和复制后 DNA 修复至关重要。最近的研究表明，除了在染色体生物学中的这种全局作用之外，粘连蛋白还被 CTCF 以及其他序列特异性 DNA 结合因子招募到特定的染色体位置。一旦就位，粘连蛋白就会在局部水平控制染色体构象。这可能是理解粘连蛋白在基因表达中的作用的关键吗？