CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They are also involved in autoimmunity, asthma, and allergic responses as well as in tumor immunity. During TCR activation in a particular cytokine milieu, naive CD4 T cells may differentiate into one of several lineages of T helper (Th) cells, including Th1, Th2, Th17, and iTreg, as defined by their pattern of cytokine production and function. In this review, we summarize the discovery, functions, and relationships among Th cells; the cytokine and signaling requirements for their development; the networks of transcription factors involved in their differentiation; the epigenetic regulation of their key cytokines and transcription factors; and human diseases involving defective CD4 T cell differentiation.

中文翻译：

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效应 CD4 T 细胞群的分化 (*)。


CD4 T 细胞在介导针对多种病原体的适应性免疫中发挥着关键作用。它们还参与自身免疫、哮喘、过敏反应以及肿瘤免疫。在特定细胞因子环境中 TCR 激活期间，幼稚 CD4 T 细胞可能分化为 T 辅助 (Th) 细胞的几种谱系之一，包括 Th1、Th2、Th17 和 iTreg，具体取决于其细胞因子产生和功能的模式。在这篇综述中，我们总结了 Th 细胞的发现、功能和关系；其发育的细胞因子和信号传导要求；参与其分化的转录因子网络；关键细胞因子和转录因子的表观遗传调控；以及涉及 CD4 T 细胞分化缺陷的人类疾病。